In a report issued by the National Institute of Mental Health 6/29/01, a study has been launched of women ages 21 to 45 who are suffering from major depression to find out whether low bone mass is related to depression or stress hormones such as Cortisol. The studies will include psychological evaluation, bone mineral testing, and measurements of stress hormones. Published research already available from many sources indicates a strong association between depression and osteoporosis. This literature suggests that depression may be a significant risk factor for osteoporosis. The NIMH study hopes to, in its way, shed light on this very important problem.